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Centanafadine hydrochloride

Name: Centanafadine hydrochloride
Brand: TargetMol
SKU: T10758L
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10758LCas No. 923981-14-0

Alias EB-1020 hydrochloride

Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).

Centanafadine hydrochloride

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Purity: 99.65%

Catalog No. T10758LAlias EB-1020 hydrochlorideCas No. 923981-14-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$257	In Stock	In Stock
50 mg	$413	In Stock	In Stock
100 mg	$648	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.65%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
Targets&IC50	5-HT:83 nM(human), Norepinephrine:6 nM (human), Dopamine:38 nM (human)
In vitro	Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters, with IC50 values of 6 nM for NE and 38 nM for DA transporters. It has a lesser effect on the 5-HT transporter, inhibiting 5-HT reuptake with an IC50 of 83 nM.
In vivo	In microdialysis studies, Centanafadine significantly increases NE and DA concentrations in the rat prefrontal cortex in vivo, with peak increases of 375% and 300%, respectively, showing the greatest effects on NE. It also raises DA extracellular concentrations in the striatum to 400% of baseline levels. Centanafadine dose-dependently reduces immobility in the mouse tail suspension test of depression to 13% of control levels without stimulating locomotor activity in adult rats at the optimal dose range. Additionally, it dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternal) as neonates.
Synonyms	EB-1020 hydrochloride

Chemical Properties

Molecular Weight	245.75
Formula	C₁₅H₁₆ClN
Cas No.	923981-14-0
Smiles	Cl.C1[C@@H]2CNC[C@]12c1ccc2ccccc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (508.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0692 mL	20.3459 mL	40.6918 mL	203.4588 mL
5 mM	0.8138 mL	4.0692 mL	8.1384 mL	40.6918 mL
10 mM	0.4069 mL	2.0346 mL	4.0692 mL	20.3459 mL
20 mM	0.2035 mL	1.0173 mL	2.0346 mL	10.1729 mL
50 mM	0.0814 mL	0.4069 mL	0.8138 mL	4.0692 mL
100 mM	0.0407 mL	0.2035 mL	0.4069 mL	2.0346 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc